This scale illustration depicts the BBB environment, fluorescent markers, therapeutic methods, and drugs. The BBB environment with glycocalyx, basement membrane, pericytes, and astrocyte end-foot processes are in microns while the molecules in the right inset are in nanometers. The left inset is not to scale to enable comparison between the competent and disrupted tight-junction.
Made for Dr. Evgenii Belykh for his paper “Blood-Brain Barrier, Blood-Brain Tumor Barrier, and Fluorescence-Guided Neurosurgical Oncology: Delivering Optical Labels to Brain Tumors”
https://www.frontiersin.org/articles/10.3389/fonc.2020.00739/full
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